
I still remember the day my dermatologist handed me a small tube and said, “This is called Zorac—it’s vitamin A. Put it on every night, and it’ll work miracles.”
I was 35 then, no wrinkles, no major sagging, but plenty of sun damage from my younger days of carefree beach holidays. The idea of a “miracle cream” that could fix it all sounded too good to resist. I rushed home, smoothed it on my face, and went to bed dreaming of luminous, baby-soft skin.
The next morning, my skin had other plans. It was red, tight, and flaking like an overbaked croissant. Within a few days, I looked like I’d been caught in a sandstorm. I had no clue what I was doing wrong, only that I looked worse than before. That was my crash course introduction to Retin-A, or prescription-strength vitamin A.
Fast forward twenty years, and I can honestly say that little tube changed my skin and my attitude toward aging. But it wasn’t magic. It took patience, mistakes, and plenty of barrier cream to learn how to use it properly.
If you’re curious about Retin-A or wondering if it’s too late to start, I’m here to tell you what really happens and how to get all the benefits without the burn.
Quick Summary: What Years of Using Retin-A Taught Me
- Start Low and Slow: Begin with 0.25% once a week and build tolerance before increasing strength.
- Apply on Dry Skin: Wait at least 20 minutes after washing your face to avoid irritation.
- Use Only a Pea-Sized Amount: More is not better, overusing leads to peeling and redness.
- Buffer with Moisturizer: Apply a barrier cream or oil (like Epionce or cacay oil) after Retin-A to calm the skin.
- Never Skip Sunscreen: Retin-A makes skin sensitive to light; daily SPF is non-negotiable.
- Be Patient: Real improvements such as smoother, firmer, glowing skin appear after 6–12 weeks.
- Don’t Expect Perfection: Retin-A softens fine lines and pigmentation but won’t erase deep wrinkles.
- Stick With It: Consistency, not intensity, delivers long-term radiance and confidence.
What Exactly Is Retin-A and Why Dermatologists Love It

Retin-A is the brand name for tretinoin, a prescription form of vitamin A. It’s part of a larger family called retinoids, which also includes milder over-the-counter retinols. What makes tretinoin special is that it’s active right away; your skin doesn’t need to convert it.
According to Harvard Health Publishing, tretinoin boosts cell turnover, helps shed old, dull skin, and stimulates new collagen growth. Over time, it improves tone, texture, and pigmentation, making it one of the few ingredients actually proven to reduce visible signs of aging (Harvard Health, 2022).
Mayo Clinic says that tretinoin was first made to treat acne, but its side effect of making skin brighter, smoother, and firmer made it very popular with dermatologists.
It’s not just about looking good for women over 50; it’s also about keeping the skin strong and healthy as cell renewal naturally slows down.
Why I Started Using Prescription Vitamin A

In my mid-30s, I didn’t have wrinkles yet, but I did have sun spots and an uneven tone. Years of living by the beach had caught up with me. So when my dermatologist mentioned vitamin A, I thought, why not get ahead of aging?
Dr. Davin Lim, a board-certified dermatologist, sums up the benefits as the 4 P’s: it helps with pimples, pores, pigmentation, and prevention. In plain terms, it clears breakouts, refines texture, fades dark spots, and helps your skin behave more youthfully.
Now in my 50s, I can confirm that it really does deliver. Prescription vitamin A purges old cells, stimulates collThe treatment increases blood flow, resulting in fresher, firmer skin, and here’s the best part: even if you’re starting at 50 or 60, your skin can still respond beautifully. You can always start at any age.
Here are some more of the incredible benefits it can have on women over 50:
- It purges old skin cell and helps new ones form
- It stimulates cells to produce collagen
- It increases blood flow
- It reverses sun damage
My Early Mistakes (or How I Accidentally Shed Like a Snake)
When I first started, I was given 1% Zorac, one of the strongest formulas out there. No one told me to go slow or that I should prep my skin first. I used it nightly, like a good student and within a week, I was peeling, red, and miserable.
It looked like I had scrubbed my face with sandpaper. I’d walk into the office with flakes on my cheeks and wonder, “Is this what miracles look like?” I finally gave up for a while because I couldn’t take the stress.
I realise now that I was making the same mistake that a lot of women do: I jumped right in. Retin-A is not a quick fix; it is a long-term investment. Everything changed once I learned how to use it right.
How I Finally Learned to Use It the Right Way

After years of trial and error, I now have a routine that gives me all the benefits with none of the misery. Here’s how I do it:
I wash my face with a gentle cleanser that doesn’t foam or strip it, and then I wait. This is very important: your face needs to be completely dry before you put on Retin-A. If your skin is wet, the cream will go deeper and make you feel worse.
After my skin is dry, I put a small amount of Stieva-A 0.05% on my face and spread it out gently. I don’t touch the corners of my mouth and nose because they peel the fastest. I also skip my chest and neck because they are much more sensitive.
After that, I use Epionce Medical Barrier Cream, which is my secret weapon. I put a little bit on top of the tretinoin. This extra layer keeps moisture in and calms the skin barrier. I don’t peel very often since I started doing this, and my skin still gets all the benefits of being younger.
Lastly, I pat some cacay oil on everything. It’s an oil from the Amazon that is full of vitamin A and antioxidants and is much gentler than retinol. I learned about it from a YouTuber named Natalie The Beauty Diva, and it’s been a game changer. It makes the skin less dry and gives it a beautiful glow by morning.
I double cleanse when I wake up to get rid of all the cream; don’t ever skip this step! Then I finish with sunscreen. Without SPF, you’re undoing all your hard work.
Tretinoin makes your skin more sun-sensitive, so protection is non-negotiable.
The “Slow and Low” Rule
If you take one thing from my experience, let it be this: go slow and start low.
My skin literally fell apart when I used 1% tretinoin every other night. Now I know that it’s better to start with a 0.25% formula once a week. After a few weeks, if your skin feels fine, move up to twice a week, then three times. When you finish the first tube, you can increase the strength to 0.5% and eventually maybe to 1%.
This gradual process gives your skin time to build tolerance. It’s like working out for your skin cells. You wouldn’t go from walking to running a marathon in one night. The American Academy of Dermatology (AAD) says that you need to be patient for retinoids to work safely.
Consistency matters more than speed. Overdoing it won’t make results come faster, it’ll just make you peel faster.
When You’ll Start Seeing Results
I saw results in a few weeks because I was too eager at first, but I also looked like I had been scrubbed with steel wool. The changes took longer to happen, but they lasted a lot longer when I switched to a slower, gentler routine.
You should start to notice changes in 6 to 12 weeks, like a smoother texture, a brighter tone, and a glow.. It takes closer to six months or more for the deeper benefits, like collagen remodelling and firmer skin, to show up.
What I love most about Retin-A is how it makes my skin look like it’s glowing from the inside out. My skin feels tighter, fresher, and more alive. It hasn’t gotten rid of my deeper lines, which are a sign of a life well-lived, but it has made my fine lines less noticeable and my skin look younger overall.
Even my dermatologist once said, “You’ve got 50-year-old skin behaving like 35.” That, to me, makes every flaky week worth it.
First vs. Third-Generation Retinoids: What’s the Difference?

Over the years, I’ve learned there are several “generations” of retinoids, each with unique traits.
- First-generation (like Stieva-A or Retrieve) are the classics; they are potent and time-tested but often irritating.
- Second-generation (Differin, or adapalene) is gentler, available over the counter, and great for sensitive skin.
- Third-generation (Zorac, or tazarotene) is powerful for exfoliation and pigmentation but can be harsh.
Dermatologists sometimes rotate or combine these because they bind to different receptors in the skin. According to research in the National Institutes of Health (NIH) database, different retinoids activate different receptor pathways, leading to varied collagen production and cell renewal responses.
If you’re advanced or working with a dermatologist, you can switch between formulations to get more benefits. But if you’re new, pick one and stick with it until your skin gets used to it.
Why Mixing Retinoids Can Be Effective (With Guidance!)
After years of experimenting, I sometimes alternate between my first-generation Stieva-A and a third-generation formula like Zorac. The reason is simple: each interacts with different skin receptors, triggering different collagen-building pathways.
This isn’t for everyone, though. I only started blending after a decade of consistent use and professional guidance. If you’re curious, talk to your dermatologist first. It’s like combining workouts; you want to train all the muscles without injury.
My Foolproof Nighttime Routine (The Gentle Glow Method)
- Cleanse gently and let skin dry completely.
- Apply a pea-sized amount of tretinoin evenly across your face, no more, no less.
- Layer with Epionce Barrier Cream to protect and calm your skin.
- Finish with cacay oil for extra hydration and glow.
- Sleep well so that the product can do the work overnight.
- Cleanse and use sunscreen every morning, no exceptions.
Over time, this routine has become a ritual. A small act of self-care that reminds me aging isn’t something to fight, but something to nurture with intention.
Common Questions I Get About Retin-A
Is it too late to start in my 50s or 60s?
Not at all. Studies show that tretinoin improves photoaged skin at any age. The process is slower, but results are real.
Can I use it with other actives like vitamin C or exfoliating acids?
Yes, but introduce them slowly and never on the same night. Alternate nights or use vitamin C in the morning.
Why does my skin look worse before it gets better?
That’s the purging phase, your skin is speeding up cell turnover, which temporarily brings imperfections to the surface. It passes within a few weeks.
What’s the most important rule?
Sunscreen. Always. Every day. Even indoors, if you’re near windows.
What Retin-A Really Did to My Skin
More than 15 years later, my skin isn’t perfect, but it’s healthy, resilient, and glows in a way makeup can’t fake. My skin is more even, my pores are smaller, and the dullness is gone.
The biggest transformation, though, isn’t just visible; it’s emotional. Using Retin-A taught me to be patient with my body. To treat aging as an evolution, not a decline. To know that true beauty isn’t about getting rid of the past but about showing the healthiest version of who you are right now.
If you decide to start, do it with intention. Go slow, protect your skin, and trust the process. It’s not a miracle cream but over time, it might just make you feel a little miraculous.
Final Thoughts
At 55, I can say that Retin-A has been my quiet little ally through the decades. It hasn’t frozen time, but it’s helped me move through it gracefully. My skin feels stronger, smoother, and more alive than it did fifteen years ago, and that’s saying something.
So, if you’re sitting there with a tiny tube in your hand, wondering whether it’s worth it, my advice is simple: start gently, be consistent, and never skip your sunscreen.
Every time you look in the mirror and think, “My skin looks happy,” your heart will also be glad.
2 Responses
Dear Schellea,
Many thanks for this interesting article on Retin A. I’ve started using it again recently.
Checked both the sites you recommend to get the cream and the oil but they are out of stock.
I was wondering if using my usual ordinary night cream would fit as well, on top the Retin A.
All the best for 2021!
Nicole
Dear Schellea,
Winter time I am using 0.2% retinol – Night Ritual Vitamin A™ cream. I mix a small amount of the cream and almost the same amount of ” Honey skin”- Ultimate body and face cream right before applying on the clean face and neck. No irritation, no red spots with that combination.
All the best
Vili